Sting1^em1Kaf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sting1^em1Kaf
• Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1, Katherine A Fitzgerald
• MGI ID: MGI:6306872
• Synonyms: SAVI N153S
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^em1Kaf page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced nucleotide substitutions to produce a serine for asparagine substitution at position 153 (N153S). (J:274277)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 49 strains or lines available

References

• Original: J:274277 Motwani M, et al., Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7941-7950
• All: 2 reference(s)