Rr70em1Rsnk
Endonuclease-mediated Allele Detail
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Symbol: |
Rr70em1Rsnk |
Name: |
regulatory region 70; endonuclease-mediated mutation 1, James Resnick |
MGI ID: |
MGI:6306477 |
Synonyms: |
ASTerm |
Gene: |
Rr70 Location: unknown Genetic Position: Chr7, Syntenic
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Alliance: |
Rr70em1Rsnk page
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: CRISPR-targeting, using sgRNAS targeting TGGCAGGATTAGCAGTTCAG and GGACTAGAGACTCTTCCACT, inserted a floxed rabbit beta-globin transcriptional terminator sequence 28.6 kb downstream of upstream exon U1 and 14.3 kb upstream of the Snrpn promoter at the Angelman syndrome imprinting center (AS-IC). Three founders were used interchangeably.
(J:270068)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Carrying any Rr70 Mutation: |
0 strains or lines available
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Original: |
J:270068 Lewis MW, et al., A mouse model of Angelman syndrome imprinting defects. Hum Mol Genet. 2019 Jan 15;28(2):220-229 |
All: |
1 reference(s) |
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