Pkn2^tm1.2Hmuk
Targeted Allele Detail

Summary

• Symbol: Pkn2^tm1.2Hmuk
• Name: protein kinase N2; targeted mutation 1.2, Hideyuki Mukai
• MGI ID: MGI:6306272
• Synonyms: Pkn2^mt
• Gene: Pkn2 Location: Chr3:142496663-142587765 bp, - strand Genetic Position: Chr3, 66.69 cM
• Alliance: Pkn2^tm1.2Hmuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274505
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 18. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 19. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 18 and 19. (J:274505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkn2 Mutation: 84 strains or lines available

References

• Original: J:274505 Danno S, et al., PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts. Genes Cells. 2017 Feb;22(2):220-236
• All: 1 reference(s)