Asxl1^tm1.1Hft
Targeted Allele Detail

Summary

• Symbol: Asxl1^tm1.1Hft
• Name: ASXL transcriptional regulator 1; targeted mutation 1.1, Hwei-Fang Tien
• MGI ID: MGI:6306114
• Synonyms: Asxl1^tm
• Gene: Asxl1 Location: Chr2:153187750-153245927 bp, + strand Genetic Position: Chr2, 75.41 cM
• Alliance: Asxl1^tm1.1Hft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274527
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A neomycin resistance cassette was inserted upstream of a modified exon 13 in which insertion of a G bp results in a G to W nonsense mutation and frame shift truncation following 12 aberrant amino acids. This mutation mimics one identified in patients with acute myeloid leukemia. Cre-mediation removed the selection cassette. (J:274527)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asxl1 Mutation: 116 strains or lines available

References

• Original: J:274527 Hsu YC, et al., The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model. J Hematol Oncol. 2017 Jul 11;10(1):139
• All: 1 reference(s)