Ephx2^tm1.1Dcz
Targeted Allele Detail

Summary

• Symbol: Ephx2^tm1.1Dcz
• Name: epoxide hydrolase 2, cytoplasmic; targeted mutation 1.1, Darryl C Zeldin
• MGI ID: MGI:6306112
• Synonyms: sEH^fl
• Gene: Ephx2 Location: Chr14:66321823-66361949 bp, - strand Genetic Position: Chr14, 34.36 cM, cytoband D
• Alliance: Ephx2^tm1.1Dcz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 11. An additional loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the selection cassette and left exons 11 and 12 floxed. (J:274977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephx2 Mutation: 41 strains or lines available

References

• Original: J:274977 Bettaieb A, et al., Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J. 2017 Jul;284(13):1970-1986
• All: 6 reference(s)