Itpa^tm1Yun
Targeted Allele Detail

Summary

• Symbol: Itpa^tm1Yun
• Name: inosine triphosphatase (nucleoside triphosphate pyrophosphatase); targeted mutation 1, Yusaku Nakabeppu
• MGI ID: MGI:6305062
• Gene: Itpa Location: Chr2:130509530-130523534 bp, + strand Genetic Position: Chr2, 63.24 cM, cytoband F3
• Alliance: Itpa^tm1Yun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299771
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Floxed Itpa allele before deletion of neo cassette. (J:299771)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itpa Mutation: 22 strains or lines available

References

• Original: J:299771 Koga Y, et al., Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy. JCI Insight. 2020 Nov 19;5(22)
• All: 1 reference(s)