Sntb1^tm1.2Scf
Targeted Allele Detail

Summary

• Symbol: Sntb1^tm1.2Scf
• Name: syntrophin, basic 1; targeted mutation 1.2, Stanley C Froehner
• MGI ID: MGI:6304309
• Synonyms: Sntb1^-, Sntb1^tm1.2Maad
• Gene: Sntb1 Location: Chr15:55499784-55770345 bp, - strand Genetic Position: Chr15, 22.14 cM
• Alliance: Sntb1^tm1.2Scf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270001
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C3H x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Deletion, Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 1. Subsequent flp-mediated recombination removed the neo cassette. Exon 1 was deleted through subsequent cre-mediated recombination. (J:270001)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sntb1 Mutation: 108 strains or lines available

References

• Original: J:270001 Kim MJ, et al., Mice lacking alpha-, beta1- and beta2-syntrophins exhibit diminished function and reduced dystrophin expression in both cardiac and skeletal muscle. Hum Mol Genet. 2019 Feb 1;28(3):386-395
• All: 3 reference(s)