Foxp1^tm1.2Jrld
Targeted Allele Detail

Summary

• Symbol: Foxp1^tm1.2Jrld
• Name: forkhead box P1; targeted mutation 1.2, Jurgen Ruland
• MGI ID: MGI:6304239
• Gene: Foxp1 Location: Chr6:98902299-99499682 bp, - strand Genetic Position: Chr6, 45.74 cM, cytoband E1
• Alliance: Foxp1^tm1.2Jrld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259650
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt-flanked neomycin selection cassette was inserted upstream of exon 10 and loxP sites were inserted to flank exons 1012. FLP-mediated recombination removed the neomycin selection cassette, leaving the loxP sites. Subsequent Cre-mediated recombination resulted in the deletion of the exon 10-12 loxP flanked region. (J:259650)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp1 Mutation: 77 strains or lines available

References

• Original: J:259650 Patzelt T, et al., Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3120-3125
• All: 1 reference(s)