Mpz^tm2.1Wra
Targeted Allele Detail

Summary

• Symbol: Mpz^tm2.1Wra
• Name: myelin protein zero; targeted mutation 2.1, Lawrence Wrabetz
• MGI ID: MGI:6304003
• Synonyms: Mpz^LoxP
• Gene: Mpz Location: Chr1:170978282-170988699 bp, + strand Genetic Position: Chr1, 79.05 cM
• Alliance: Mpz^tm2.1Wra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267903
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin selection cassette was inserted downstream of exon 5 and subsequently removed via cre-mediated recombination. This allele, for which two lines (LoxPA3 and LoxPD1) were established, is a control for Mpz^tm1.1Wra. (J:267903)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpz Mutation: 28 strains or lines available

References

• Original: J:267903 Fratta P, et al., A nonsense mutation in myelin protein zero causes congenital hypomyelination neuropathy through altered P0 membrane targeting and gain of abnormal function. Hum Mol Genet. 2019 Jan 1;28(1):124-132
• All: 1 reference(s)