Unc93b1^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Unc93b1^em1Btlr
• Name: unc-93 homolog B1, TLR signaling regulator; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6303989
• Gene: Unc93b1 Location: Chr19:3985222-3999340 bp, + strand Genetic Position: Chr19, 3.65 cM
• Alliance: Unc93b1^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The CRISPR/Cas9 system and sgRNA 5'-AGGAAGTCCCAACCAGCTGC-3' was used to generate the mice. The CRISPR/Cas9 system generated a 109-base pair deletion at c.138_28del (NM_019449.2). The mutation is predicted to cause a frame-shifted protein product beginning after amino acid 7 of the protein and premature termination after the inclusion of 63 aberrant amino acids. (J:274652)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc93b1 Mutation: 41 strains or lines available

References

• Original: J:274652 Wang K, et al., Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice. Proc Natl Acad Sci U S A. 2019
• All: 1 reference(s)