Il1r2^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Il1r2^tm1.1Itl
• Name: interleukin 1 receptor, type II; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:6303954
• Synonyms: IL-1R2^flx
• Gene: Il1r2 Location: Chr1:40123872-40164390 bp, + strand Genetic Position: Chr1, 18.65 cM
• Alliance: Il1r2^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247674
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 was conditionally targeted by inserting a loxP/FRT-flanked pGK-gb2-Neo cassette in intron 3 and a single loxP cassette into intron 2. The FRT-flanked Neo cassette was removed via FLP mediated recombination. (J:247674)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1r2 Mutation: 34 strains or lines available

References

• Original: J:247674 Martin P, et al., Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses. J Immunol. 2017 Apr 01;198(7):2916-2926
• All: 1 reference(s)