Rr157^em1Fee
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr157^em1Fee
• Name: regulatory region 157; endonuclease-mediated mutation 1, Ann J Feeney
• MGI ID: MGI:6303852
• Synonyms: E88delta, Igk^em1Fee
• Gene: Rr157 Location: Chr6:68861137-68861380 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr157^em1Fee page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: A 1161 bp sequence in Igk variable region enhancer E88 spanning E2A and EBF binding sites, was deleted in mice using CRISPR/Cas9 genome editing. (J:273872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr157 Mutation: 0 strains or lines available

References

• Original: J:273872 Barajas-Mora EM, et al., A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire. Mol Cell. 2019 Jan 3;73(1):48-60.e5
• All: 1 reference(s)