Lcn3^em2Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lcn3^em2Btlr
• Name: lipocalin 3; endonuclease-mediated mutation 2, Bruce Beutler
• MGI ID: MGI:6303843
• Gene: Lcn3 Location: Chr2:25655581-25658111 bp, + strand Genetic Position: Chr2, 17.99 cM, cytoband A3
• Alliance: Lcn3^em2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The CRISPR/Cas9 system and sgRNA 5'-AGACGACATCCCAATAAACA-3' was used to generate the mice. The CRISPR/Cas9 system generated a 16-base pair deletion TGTGAAGGGCCACTAC at c.367_401del (NM_010694.2). The mutation is predicted to cause a frame-shifted protein product beginning after amino acid 112 of the protein and termination after the inclusion of seven aberrant amino acids. (J:274568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcn3 Mutation: 9 strains or lines available

References

• Original: J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)
• All: 1 reference(s)