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Gt(ROSA)26Sortm1.1(UBC-flpe)Ozg
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1.1(UBC-flpe)Ozg
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Ozgene
MGI ID: MGI:6297051
Synonyms: OzFlp, Ubic-Flpe
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:274081
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA flpe recombinase transgene, driven by the human ubiquitin C promoter, was inserted into intron 1. Downstream of the gene the transgene cassette also contains bovine growth hormone (BGH) polyadenylation signal sequence and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed by breeding to cre allele carying mice. (J:274081)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: UBC     Summary of all recombinase alleles driven by UBC.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  731 strains or lines available
References
Original:  J:274081 Rashidi M, et al., CD52 inhibits Toll-like receptor activation of NF-kappaB and triggers apoptosis to suppress inflammation. Cell Death Differ. 2018 Feb;25(2):392-405
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory