Cd52^tm1.2Lech
Targeted Allele Detail

Summary

• Symbol: Cd52^tm1.2Lech
• Name: CD52 antigen; targeted mutation 1.2, Leonard C Harrison
• MGI ID: MGI:6295935
• Synonyms: CD52^-
• Gene: Cd52 Location: Chr4:133820849-133822384 bp, - strand Genetic Position: Chr4, 66.5 cM
• Alliance: Cd52^tm1.2Lech page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274081
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site into intron 2. The FRT site flanked neomycin resistance gene cassette that was also inserted, was removed through subsequent flp-mediated recombination. Exon 2 was deleted through subsequent cre-mediated recombination. (J:274081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd52 Mutation: 14 strains or lines available

References

• Original: J:274081 Rashidi M, et al., CD52 inhibits Toll-like receptor activation of NF-kappaB and triggers apoptosis to suppress inflammation. Cell Death Differ. 2018 Feb;25(2):392-405
• All: 1 reference(s)