Tg(Prnp-MAPT*P130L)23027Shoj
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT*P130L)23027Shoj
• Name: transgene insertion 23207, Mikio Shoji
• MGI ID: MGI:6295463
• Synonyms: FTDP-17, TgTau^P301L, TgTau(P301L)23027
• Transgene: Tg(Prnp-MAPT*P130L)23027Shoj Location: unknown
• Alliance: Tg(Prnp-MAPT*P130L)23027Shoj page

Transgene origin

• Strain of Origin: (129S1/Sv FVB/N)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The longest isoform of human 2N4R wild-type (wt) tau (MAPT) cDNA containing a eukaryotic Kozak initiation sequence upstream of the start codon was ligated to the SalI-digested site of a linearized cos- Tet expression vector containing the Syrian hamster prion protein gene promoter. (J:113391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:113391 Murakami T, et al., Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. Am J Pathol. 2006 Oct;169(4):1365-75
• All: 12 reference(s)