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Endonuclease-mediated Allele Detail
Symbol: Chchd10em10Lutzy
Name: coiled-coil-helix-coiled-coil-helix domain containing 10; endonuclease-mediated mutation 10, Cathy Lutz
MGI ID: MGI:6295437
Synonyms: Chchd10R15L
Gene: Chchd10  Location: Chr10:75933130-75937747 bp, + strand  Genetic Position: Chr10, 38.62 cM
Strain of Origin:  C57BL/6NJ
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Nucleotide substitutions
Mutation detailsCRISPR/Cas9 genome editing is used to introduce the R15L substitution (CGC to CTC codon change). In humans, the R15L substitution is associated with amyotrophic lateral sclerosis. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chchd10 Mutation:  13 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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