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Abca8aem1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: Abca8aem1(IMPC)J
Name: ATP-binding cassette, sub-family A member 8a; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6294772
Gene: Abca8a  Location: Chr11:109916460-109986804 bp, - strand  Genetic Position: Chr11, 73.07 cM
Alliance: Abca8aem1(IMPC)J page
IMPC: Abca8a gene page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ACAGAGTCTTTCCTCTAAGT and GCTTACCCTATCACTACGTA, which resulted in a 1110 bp deletion beginning at Chromosome 11 position 110,071,149 bp and ending after 110,072,258 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000342464 and ENSMUSE00001068496 (exons 11 and 12) and 940 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 478 and early truncation 5 amino acids later. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Abca8a Mutation:  103 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory