Hdac9^em1Birn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hdac9^em1Birn
• Name: histone deacetylase 9; endonuclease-mediated mutation 1, Ramon Y Birnbaum
• MGI ID: MGI:6294466
• Synonyms: eTw5-7 delta
• Gene: Hdac9 Location: Chr12:34097579-34967094 bp, - strand Genetic Position: Chr12, 15.06 cM, cytoband B2
• Alliance: Hdac9^em1Birn page

Mutation origin

• Strain of Origin: C57BL

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas technology, a 23 kb sequence in the Hdac9 gene containing all three enhancers eTw5-7 (Rr134-Rr136) of the Twist1 gene and exons 17-20 of Hdac9 gene (23,137bp; chr12:34883773-34906909; mm9) was removed. (J:269305)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac9 Mutation: 52 strains or lines available

References

• Original: J:269305 Hirsch N, et al., Unraveling the transcriptional regulation of TWIST1 in limb development. PLoS Genet. 2018 Oct;14(10):e1007738
• All: 1 reference(s)