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Tg(Prnp-HTT*82Q)8AGschi
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-HTT*82Q)8AGschi
Name: transgene insertion 8A, Gabriele Schilling
MGI ID: MGI:6294291
Synonyms: NLS-N171-82Q
Transgene: Tg(Prnp-HTT*82Q)8AGschi  Location: unknown  
Transgene
origin
Strain of Origin:  (C3H/HeJ x C57BL/6J)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-HTT*82Q)8AGschi expresses 1 gene
 
Mutation detailsThe first 171 amino acids of human huntingtin with an expanded glutamine tract of 82 glutamines fused at the N-terminus to the nuclear localization signal sequence from atrophin-1 (first 30 amino acids) is under the control of the mouse prion protein promoter. Western blot and immunohistochemical analyses confirmed that the huntingtin fragments accumulate in nuclear, but not cytoplasmic, compartments. (J:91795)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:91795 Schilling G, et al., Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice. Hum Mol Genet. 2004 Aug 1;13(15):1599-610
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory