Gt(ROSA)26Sor^{tm2(OXSR1*)Clhu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(OXSR1*)Clhu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Chou-Long Huang
• MGI ID: MGI:6294277
• Synonyms: ROSA26-hOSR1^ca
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(OXSR1*)Clhu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197855
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(OXSR1*)Clhu} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  OXSR1 (9943)

  Oxsr1

  (MGI:1917378)

  A constituitively active form with T185E and S325E amino acid substitutions

• Mutation details: A constituitively active form of human Oxsr1 with T185E and S325E amino acid substitutions preceeded by a floxed neomycin resistance/STOP cassette was inserted into the locus. (J:197855)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1097 strains or lines available

References

• Original: J:197855 Xie J, et al., WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade. J Biol Chem. 2013 Mar 22;288(12):8566-74
• All: 1 reference(s)