Rab4b^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Rab4b^tm1.1Ics
• Name: RAB4B, member RAS oncogene family; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:6294246
• Synonyms: Rab4b^flox
• Gene: Rab4b Location: Chr7:26867858-26878308 bp, - strand Genetic Position: Chr7, 15.84 cM
• Alliance: Rab4b^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271040
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked PGK-neomycin resistance cassette was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2-3 floxed. (J:271040)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab4b Mutation: 19 strains or lines available

References

• Original: J:271040 Gilleron J, et al., Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance. Cell Rep. 2018 Dec 18;25(12):3329-3341.e5
• All: 1 reference(s)