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U2af1em1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: U2af1em1(IMPC)J
Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6294123
Gene: U2af1  Location: Chr17:31866055-31877866 bp, - strand  Genetic Position: Chr17, 17.02 cM
Alliance: U2af1em1(IMPC)J page
IMPC: U2af1 gene page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GCCCACTCCTCACTAAAGCC and GTCACTATAGCTGAGCTCGA, which resulted in a 323 bp deletion beginning at Chromosome 17 position 31,648,622 bp and ending after 31,648,944 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000137465 and ENSMUSE00000137461 (exons 4 and 5) and 174 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 66 and early truncation 3 amino acids later. There is a single base pair, A, insertion at the deletion site. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any U2af1 Mutation:  33 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory