Oxr1^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Oxr1^{tm1d(EUCOMM)Wtsi}
• Name: oxidation resistance 1; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:6287669
• Synonyms: Oxr1^tm1d
• Gene: Oxr1 Location: Chr15:41310878-41724444 bp, + strand Genetic Position: Chr15, 16.06 cM, cytoband D1
• Alliance: Oxr1^{tm1d(EUCOMM)Wtsi} page
• IMPC: Oxr1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273206
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 41716378 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 41718528. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:273206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxr1 Mutation: 36 strains or lines available

References

• Original: J:273206 Finelli MJ, et al., Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase. Mol Neurobiol. 2019 Mar;56(3):1558-1577
• All: 1 reference(s)