Rcan1^tm2.1Mrco
Targeted Allele Detail

Summary

• Symbol: Rcan1^tm2.1Mrco
• Name: regulator of calcineurin 1; targeted mutation 2.1, Miguel R Campanero
• MGI ID: MGI:6287459
• Synonyms: Rcan1-4^-
• Gene: Rcan1 Location: Chr16:92188839-92263057 bp, - strand Genetic Position: Chr16, 53.6 cM
• Alliance: Rcan1^tm2.1Mrco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268611
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the selection cassette. This allele prevents expression of isoform Rcan1-4. (J:268611)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rcan1 Mutation: 26 strains or lines available

References

• Original: J:268611 Villahoz S, et al., Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. Nat Commun. 2018 Nov 15;9(1):4795
• All: 1 reference(s)