Lmna^tm4.1Stw
Targeted Allele Detail

Summary

• Symbol: Lmna^tm4.1Stw
• Name: lamin A; targeted mutation 4.1, Colin L Stewart
• MGI ID: MGI:6287402
• Synonyms: Lmna^delta
• Gene: Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
• Alliance: Lmna^tm4.1Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193454
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion, Single point mutation
• Mutation details: A loxP site was inserted upstream of exon 10 and a loxP site was inserted in the 3' UTR before exon 12. Cre-mediated recombincation removed the 3' UTR. (J:193454)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmna Mutation: 84 strains or lines available

References

• Original: J:193454 Solovei I, et al., LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell. 2013 Jan 31;152(3):584-98
• All: 4 reference(s)