Kdm6a^tm1.1Yuuki
Targeted Allele Detail

Summary

• Symbol: Kdm6a^tm1.1Yuuki
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1.1, Yuuki Imai
• MGI ID: MGI:6287397
• Synonyms: Utx^flox
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^tm1.1Yuuki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273115
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:273115)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 37 strains or lines available

References

• Original: J:273115 Suzuki J, et al., The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation. Nat Commun. 2018 Aug 17;9(1):3296
• All: 4 reference(s)