Sirt7^tm1.2Auw
Targeted Allele Detail

Summary

• Symbol: Sirt7^tm1.2Auw
• Name: sirtuin 7; targeted mutation 1.2, Johan Auwerx
• MGI ID: MGI:6287251
• Gene: Sirt7 Location: Chr11:120509197-120515840 bp, - strand Genetic Position: Chr11, 84.34 cM
• Alliance: Sirt7^tm1.2Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272987
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 6, and second loxP site, followed by an FRT-flanked neomycin selection cassette, downstream of exon 9. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 6 through 9 floxed. Cre-mediated recombination removed exons 6 through 9. (J:272987)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt7 Mutation: 20 strains or lines available

References

• Original: J:272987 Ryu D, et al., A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function. Cell Metab. 2014 Nov 4;20(5):856-869
• All: 4 reference(s)