Dicer1^tm1.1Smr
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1.1Smr
• Name: dicer 1, ribonuclease type III; targeted mutation 1.1, Sarah E Millar
• MGI ID: MGI:6287204
• Synonyms: Dicer1^excised
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1.1Smr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192105
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 22 and 23 were flanked by loxP sites and removed by cre-mediated recombination. (J:192105)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:192105 Greenlee AR, et al., Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1. PLoS One. 2012;7(10):e46359
• All: 2 reference(s)