Kat2a^tm1Auw
Targeted Allele Detail

Summary

• Symbol: Kat2a^tm1Auw
• Name: K(lysine) acetyltransferase 2A; targeted mutation 1, Johan Auwerx
• MGI ID: MGI:6287127
• Synonyms: GCN5^flox, Gcn5^L2
• Gene: Kat2a Location: Chr11:100595572-100603291 bp, - strand Genetic Position: Chr11, 63.53 cM
• Alliance: Kat2a^tm1Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326596
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP site upstream of exon 5, and second loxP site, followed by an FRT-flanked neomycin selection cassette, downstream of exon 6. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 5 and 6 floxed. (J:326596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kat2a Mutation: 40 strains or lines available

References

• Original: J:326596 Addicks GC, et al., GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression. J Cell Biol. 2022 Feb 7;221(2):e202104022
• All: 1 reference(s)