Wnk1^tm1.1Tyb
Targeted Allele Detail

Summary

• Symbol: Wnk1^tm1.1Tyb
• Name: WNK lysine deficient protein kinase 1; targeted mutation 1.1, Victor LJ Tybulewicz
• MGI ID: MGI:6286266
• Synonyms: Wnk1^D368A
• Gene: Wnk1 Location: Chr6:119900930-120015633 bp, - strand Genetic Position: Chr6, 56.86 cM
• Alliance: Wnk1^tm1.1Tyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259583
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 3 was replaced with a modified exon containing the nucleotide substitution (AC to CT) and results in the amino acid substitution of alanine for aspartic acid at position 368 (D368A). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:259583)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk1 Mutation: 115 strains or lines available

References

• Original: J:259583 Kochl R, et al., WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol. 2016 Sep;17(9):1075-83
• All: 4 reference(s)