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Arid1bem1Iha
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Arid1bem1Iha
Name: AT rich interactive domain 1B (SWI-like); endonuclease-mediated mutation 1, Izuho Hatada
MGI ID: MGI:6286071
Gene: Arid1b  Location: Chr17:4994332-5347656 bp, + strand  Genetic Position: Chr17, 2.83 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology using the Cas9D10A and gRNAs 5'-CCAGGCACAGTACCTGCAGC-3' and 5'-GGCGGGAGGTGCGAGGGCTG-3', generated a deletion in exon 3 that causes a frameshift in translation and premature termination. RNA expression in whole brain of heterozygotes is reduced to about 70% of the level in wild-type while protein is reduced to about 50% of that in wild-type mice. (J:271850)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arid1b Mutation:  25 strains or lines available
References
Original:  J:271850 Shibutani M, et al., Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice. Int J Mol Sci. 2017 Aug 30;18(9)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory