Lyn^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lyn^m4Btlr
• Name: LYN proto-oncogene, Src family tyrosine kinase; mutation 4, Bruce Beutler
• MGI ID: MGI:6285919
• Synonyms: water
• Gene: Lyn Location: Chr4:3676865-3791612 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 3,748,787 (v38) on chromosome 4, or base pair 70,667 in the GenBank genomic region NC_000070 encoding Lyn. The mutation corresponds to residue 1,013 in the mRNA sequence NM_001111096 within exon 8 of 13 total exons. The mutation results in an alanine to valine substitution at position 255 (A255V) in the LYN protein. (J:272816)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 64 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3777

References

• Original: J:272816 Zhong X, et al., Mutagenetix entry for water. MGI Direct Data Submission. 2019
• All: 1 reference(s)