Neo1^tm1.1Jfcl
Targeted Allele Detail

Summary

• Symbol: Neo1^tm1.1Jfcl
• Name: neogenin; targeted mutation 1.1, Jean-Francois Cloutier
• MGI ID: MGI:6285614
• Synonyms: Neo1^lox
• Gene: Neo1 Location: Chr9:58781970-58943724 bp, - strand Genetic Position: Chr9, 31.81 cM
• Alliance: Neo1^tm1.1Jfcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1, and an frt flanked neomycin cassette and another loxP site was inserted downstream of exon 1 by homologous recombination. The neomycin cassette was removed through Flp-mediated recombination resulting in an allele with a floxable exon 1. Western blot on extracts derived from brain of homozygous animals, following Cre-mediated excision of exon 1, did not detect any protein product. (J:235517)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neo1 Mutation: 63 strains or lines available

References

• Original: J:235517 Kam JW, et al., RGMB and neogenin control cell differentiation in the developing olfactory epithelium. Development. 2016 May 1;143(9):1534-46
• All: 7 reference(s)