Prkdc^m17Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkdc^m17Btlr
• Name: protein kinase, DNA activated, catalytic polypeptide; mutation 17, Bruce Beutler
• MGI ID: MGI:6285488
• Synonyms: updock
• Gene: Prkdc Location: Chr16:15455730-15660099 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Prkdc^m17Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 15,795,094 (v38) on chromosome 16, or base pair 157,652 in the GenBank genomic region NC_000082 for Prkdc. The mutation corresponds to residue 9,538 in the mRNA sequence NM_011159 within exon 68 of 86 total exons. The mutation results in a valine to alanine substitution at position 3,172 (V3172A) in the DNA-PKCS protein. (J:272521)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkdc Mutation: 408 strains or lines available

References

• Original: J:272521 Zhong X, et al., Mutagenetix entry for updock. MGI Direct Data Submission. 2019
• All: 1 reference(s)