Del(11Krt31c)2Tmm
Targeted Allele Detail

Summary

• Symbol: Del(11Krt31c)2Tmm
• Name: deletion, Chr 11, Thomas M Magin 2
• MGI ID: MGI:6283859
• Synonyms: Del(11Krt222-Krt17)2Tmm, Del2Tmm, KtyI^-
• Gene: Del(11Krt31c)2Tmm Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230728
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(11Krt31c)2Tmm involves 76 genes/genome features (Gm32502, Krt222, Gm32385 ...) View all
• Mutation details: LoxP sites were inserted 5' and 3' of the keratin type I gene cluster. Cre mediated recombination deleted the entire cluster leaving a single loxP site from Krt222 to Krt17. The absence of the transcripts and gene products was confirmed by RT-PCR and immunofluorescence microscopy in homozygous embryos. ES cells carrying Krt31c^tm1Tmm and Krt31c^tm2Tmm and were used to create this deletion. (J:230728)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Krt31c)2Tmm Mutation: 0 strains or lines available

References

• Original: J:230728 Kumar V, et al., A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015 Dec 7;211(5):1057-75
• All: 2 reference(s)