Igf2bp2^tm2.1Mini
Targeted Allele Detail

Summary

• Symbol: Igf2bp2^tm2.1Mini
• Name: insulin-like growth factor 2 mRNA binding protein 2; targeted mutation 2.1, Liliana Minichiello
• MGI ID: MGI:6283825
• Synonyms: Imp2^f
• Gene: Igf2bp2 Location: Chr16:21877759-21982049 bp, - strand Genetic Position: Chr16, 13.02 cM
• Alliance: Igf2bp2^tm2.1Mini page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272020
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downsteam of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:272020)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf2bp2 Mutation: 89 strains or lines available

References

• Original: J:272020 Regue L, et al., IMP2 increases mouse skeletal muscle mass and voluntary activity by enhancing autocrine IGF2 production and optimizing muscle metabolism. Mol Cell Biol. 2019 Jan 28
• All: 4 reference(s)