Mir449a^tm1.1Doca
Targeted Allele Detail

Summary

• Symbol: Mir449a^tm1.1Doca
• Name: microRNA 449a; targeted mutation 1.1, Donal O'Carroll
• MGI ID: MGI:6283348
• Synonyms: 449^-
• Gene: Mir449a Location: Chr13:113174068-113174158 bp, + strand Genetic Position: Chr13, 63.93 cM
• Alliance: Mir449a^tm1.1Doca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228491
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The pre-microRNA sequence within intron 2 of Cdc20b (MGI:3644472) was replaced with a floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. (J:228491)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir449a Mutation: 2 strains or lines available

References

• Original: J:228491 Comazzetto S, et al., Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci. PLoS Genet. 2014 Oct;10(10):e1004597
• All: 1 reference(s)