Mirc21^tm1.1Doca
Targeted Allele Detail

Summary

• Symbol: Mirc21^tm1.1Doca
• Name: microRNA cluster 21, including Mir34c through Mir34b; targeted mutation 1.1, Donal O'Carroll
• MGI ID: MGI:6283346
• Gene: Mirc21 Location: Chr9:51014334-51014945 bp Genetic Position: Chr9, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228491
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of the pre-Mir34b seqeunce. An additional loxP site was inserted downstream of the pre-Mir34c sequence. Flp-mdiated recombination removed the selection cassette and left the pre-microRNS sequences floxed. (J:228491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc21 Mutation: 5 strains or lines available

References

• Original: J:228491 Comazzetto S, et al., Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci. PLoS Genet. 2014 Oct;10(10):e1004597
• All: 1 reference(s)