Tet2^tm1.2Gxu
Targeted Allele Detail

Summary

• Symbol: Tet2^tm1.2Gxu
• Name: tet methylcytosine dioxygenase 2; targeted mutation 1.2, Guo-Liang Xu
• MGI ID: MGI:6282904
• Synonyms: Tet2^tm1.2Gux
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^tm1.2Gxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239417
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP was inserted upstream of exon 9. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 9 and 10. (J:239417)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 783 strains or lines available

References

• Original: J:239417 Dai HQ, et al., TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 Oct 27;538(7626):528-532
• All: 5 reference(s)