Mir137^tm1.1Penj
Targeted Allele Detail

Summary

• Symbol: Mir137^tm1.1Penj
• Name: microRNA 137; targeted mutation 1.1, Peng Jin
• MGI ID: MGI:6282027
• Synonyms: Mir137^-
• Gene: Mir137 Location: Chr3:118227506-118227578 bp, + strand Genetic Position: Chr3, 51.71 cM
• Alliance: Mir137^tm1.1Penj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271669
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the gene and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted downstream. The gene and selection cassette were deleted in the germline through cre-mediated recombination by crossing mice carying the floxed allele with Zp3-cre allele carying mice. This creates a knockout allele. (J:271669)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir137 Mutation: 5 strains or lines available

References

• Original: J:271669 Cheng Y, et al., Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nat Neurosci. 2018 Dec;21(12):1689-1703
• All: 1 reference(s)