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Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber
Name: transgene insertion 3798, Silke Nuber
MGI ID: MGI:6281748
Synonyms: 3KL, Thy1-3K alpha S
Transgene: Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber expresses 1 gene
 
Mutation detailsThe transgene contains a Thy1 promoter sequence directing expression of a modified human alpha synuclein cDNA carrying the E35K, E46K and E61K mutations. Founder line 3798 with low overexpression was subsequently established. (J:268903)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:268903 Nuber S, et al., Abrogating Native alpha-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 Oct 10;100(1):75-90.e5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory