Jak1^tm1.1Hko
Targeted Allele Detail

Summary

• Symbol: Jak1^tm1.1Hko
• Name: Janus kinase 1; targeted mutation 1.1, Haruhiko Koseki
• MGI ID: MGI:6281710
• Gene: Jak1 Location: Chr4:101009564-101122479 bp, - strand Genetic Position: Chr4, 46.19 cM
• Alliance: Jak1^tm1.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237080
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A CGT to CAT point mutation in exon 19 results in the amino acid substitution of histidine for arginine at position 878 (R878H). Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:237080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak1 Mutation: 49 strains or lines available

References

• Original: J:237080 Yasuda T, et al., Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. J Clin Invest. 2016 Jun 01;126(6):2064-76
• All: 1 reference(s)