Tet2^tm1.1Gxu
Targeted Allele Detail

Summary

• Symbol: Tet2^tm1.1Gxu
• Name: tet methylcytosine dioxygenase 2; targeted mutation 1.1, Guo-Liang Xu
• MGI ID: MGI:6281673
• Synonyms: Tet2^f, Tet2^tm1.1Gux
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^tm1.1Gxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239417
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP was inserted upstream of exon 9. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette and left exons 9 and 10 floxed. (J:266625)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 781 strains or lines available

Notes

This allele was generated in ES cells containing Tet1^tm1Gxu and Tet3^tm1.1Gxu. J:266625

References

• Original: J:239417 Dai HQ, et al., TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 Oct 27;538(7626):528-532
• All: 5 reference(s)