Map4k1^tm2.1Gne
Targeted Allele Detail

Summary

• Symbol: Map4k1^tm2.1Gne
• Name: mitogen-activated protein kinase kinase kinase kinase 1; targeted mutation 2.1, Genentech
• MGI ID: MGI:6281378
• Synonyms: Map4k1 M91A
• Gene: Map4k1 Location: Chr7:28681506-28702704 bp, + strand Genetic Position: Chr7, 16.94 cM, cytoband A3
• Alliance: Map4k1^tm2.1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271193
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector inserted an ATGGAA to GCGGAG mutation in exon 4 (includes a silent mutation to remove an EcoRI site) resulting in a methionine to a substitution at amino acid 91 (M91A) and a FRT-flanked PGK1-neomycin cassette. Flp-mediated recombination in ES cells removed the selection cassette. (J:271193)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map4k1 Mutation: 56 strains or lines available

References

• Original: J:271193 Hernandez S, et al., The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function. Cell Rep. 2018 Oct 2;25(1):80-94
• All: 1 reference(s)