Art1^1.1Fkn
Targeted Allele Detail

Summary

• Symbol: Art1^1.1Fkn
• Name: ADP-ribosyltransferase 1; targeted mutation 1.1, Friedrich Koch-Nolte
• MGI ID: MGI:6281332
• Synonyms: Artc1^-
• Gene: Art1 Location: Chr7:101750950-101763140 bp, + strand Genetic Position: Chr7, 54.71 cM
• Alliance: Art1^1.1Fkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271260
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and a PGK-neomycin resistance cassette were inserted upstream of exon 3 and a second loxP site was inserted downstream of exon 4. Cre-mediated recombination deleted exons 3 and 4, leaving the neomycin cassette. (J:271260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Art1 Mutation: 25 strains or lines available

References

• Original: J:271260 Leutert M, et al., Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme. Cell Rep. 2018 Aug 14;24(7):1916-1929.e5
• All: 1 reference(s)