Rela^tm1.1Bras
Targeted Allele Detail

Summary

• Symbol: Rela^tm1.1Bras
• Name: Rela proto-oncogene, NFKB subunit; targeted mutation 1.1, Allan R Brasier
• MGI ID: MGI:6281191
• Synonyms: RelA^CKO
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1.1Bras page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235787
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and frt-flanked neomycin selection cassette were inserted about 0.6-kb upstream of exon 5. A second loxP site was inserted about 240-bp downstream of exon 8. Flp-mediated recombination removed the neomycin cassette, leaving exons 5-8 floxed. (J:235787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:235787 Ijaz T, et al., Generation and characterization of a novel transgenic mouse harboring conditional nuclear factor-kappa B/RelA knockout alleles. BMC Dev Biol. 2016 Sep 23;16(1):32
• All: 3 reference(s)