Cmas^tm1.1Bwei
Targeted Allele Detail

Summary

• Symbol: Cmas^tm1.1Bwei
• Name: cytidine monophospho-N-acetylneuraminic acid synthetase; targeted mutation 1.1, Birgit Weinhold
• MGI ID: MGI:6281180
• Synonyms: Cmas^floxed
• Gene: Cmas Location: Chr6:142702468-142721440 bp, + strand Genetic Position: Chr6, 74.66 cM
• Alliance: Cmas^tm1.1Bwei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271312
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 4. The neo cassette was removed through subsequent flp-mediated recombination, leaving a condional-ready allele with exon 4 floxed. (J:271312)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cmas Mutation: 28 strains or lines available

References

• Original: J:271312 Abeln M, et al., Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro. Chembiochem. 2017 Jul 4;18(13):1305-1316
• All: 3 reference(s)