Grxcr2^em1Bzha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grxcr2^em1Bzha
• Name: glutaredoxin, cysteine rich 2; endonuclease-mediated mutation 1, Bo Zhao
• MGI ID: MGI:6281113
• Synonyms: Grxcr2^D46
• Gene: Grxcr2 Location: Chr18:42118388-42132114 bp, - strand Genetic Position: Chr18, 22.14 cM
• Alliance: Grxcr2^em1Bzha page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 46 bp deletion in exon 1. The frameshift caused by the deletion creates an early stop codon. (J:271271)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grxcr2 Mutation: 13 strains or lines available

References

• Original: J:271271 Liu C, et al., GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing. Cell Rep. 2018 Oct 30;25(5):1268-1280.e4
• All: 3 reference(s)