Cenpa^tm1Dimi
Targeted Allele Detail

Summary

• Symbol: Cenpa^tm1Dimi
• Name: centromere protein A; targeted mutation 1, Stefan Dimitrov
• MGI ID: MGI:6281002
• Synonyms: CENP-A cKO/KI
• Gene: Cenpa Location: Chr5:30824214-30832181 bp, + strand Genetic Position: Chr5, 16.76 cM
• Alliance: Cenpa^tm1Dimi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249126
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag)
• Mutation: Insertion
• Mutation details: The gene was replaced with an HA-Flag tagged Cenpa fusion gene in which exon 1 is flanked with loxP sites via homologous recombination. (J:249126)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cenpa Mutation: 15 strains or lines available

References

• Original: J:249126 Roulland Y, et al., The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity. Mol Cell. 2016 Aug 18;63(4):674-685
• All: 1 reference(s)